Mystery creates wonder and wonder is the basis of man's desire to understand.

The stars don't look bigger, but they do look brighter.

This is one small step for a man, one giant leap for mankind.

That's one small step for [a] man, one giant leap for mankind

Houston, Tranquillity Base here. The Eagle has landed.

When you look at the stars and the galaxy, you feel that you are not just from any particular piece of land, but from the solar system.

All adventures, especially into new territory, are scary.

I don't know what you could say about a day in which you have seen four beautiful sunsets.

It took me a long time to get selected as an astronaut.

In fact, I applied for 20 years before I was selected.

But I found that being an artist and doing accurate work is very difficult.

Be thankful for problems. If they were less difficult, someone with less ability might have your job.

I'll tell you, being involved in human space flight, it is an emotional endeavor. I think it brings in the highest highs and the lowest lows.

That's one small step for a man, one giant leap for mankind.

Certainly my parents were a huge influence.

They always expected the most out of all of us. And expected us to do our very best. I'm thankful to them for allowing me to do what I wanted to do.

We can see cities during the day and at night, and we can watch rivers dump sediment into the ocean, and see hurricanes form.

Although I know a lot of the previous shuttle flights, in theory, had their tasks laid out; but there were still some changes that came along for them.

After assembly complete, when we have a larger crew on orbit, a more complex vehicle, more laboratories and more robot arms, maybe we'll have room for specialists. But right now we don't.

A civilization that only looks inward will stagnate.

We have to keep looking outward; we have to keep finding new avenues for human endeavor and human expression.

It so happened that my goals kind of matched my career progression toward becoming an astronaut.

At least believe this many humans, who are interested obviously in this topic.

Many of them visited me after lectures and meetings, in hope that I can give concrete answers to their questions. For it was clear: If that does not know it, who is to then know it?

I think humans will reach Mars, and I would like to see it happen in my lifetime.

Problems look mighty small from 150 miles up.

There is still no cure for the common birthday.

I don't know why I always liked aerospace engineering.

I was in the 10th grade when I figured that's what I wanted to do.

We have no proof, but if we extrapolate, based on the best information we have available to us, we have to come to the conclusion that ... other life probably exists out there and perhaps in many places...

It suddenly struck me that that tiny pea, pretty and blue, was the Earth.

I put up my thumb and shut one eye, and my thumb blotted out the planet Earth. I didn't feel like a giant. I felt very, very small.

Science has not yet mastered prophecy.

We predict too much for the next year and yet far too little for the next 10.

I believe that the Good Lord gave us a finite number of heartbeats and I'm damned if I'm going to use up mine running up and down a street.

Mystery creates wonder and wonder is the basis of our desire to understand.

It's like trying to describe what you feel when you're standing on the rim of the Grand Canyon or remembering your first love or the birth of your child. You have to be there to really know what it's like.

But I don't think we'll go there until we go back to the moon and develop a technology base for living and working and transporting ourselves through space.

It's great that people are interested in Mars.

When you talk to crews that went to Mir or have gone up to International Space Station, they say that you go through different phases of adaptation or getting used to the space environment.

We've had such thorough training, we've had an excellent team on the ground.

With the minor glitches that have occurred, we've been able to take care of them. And the teams on the ground are getting tons of incredible data.

We're looking at Earth science, observing our planet.

Also space science, looking at the ozone in the atmosphere around our Earth. Also looking at life science. And on a human level, using ourselves as test subjects.

We'd like to have immediate answers to all of our questions.

I think medicine in particular. I found it frustrating as a physician sometimes to not be able to tell someone exactly why something was happening to them. There are still so many mysteries in medicine.

We trained for a lot more malfunctions than any ever happen.

This has been a great experience for me.

The first couple of days you don't always feel too well. You adjust to the fluid shifting, how to fly through space without hitting things or anybody else. But then you get in a groove.

Things are going very smoothly. As expected, there are some minor glitches, and the eight minutes that it took us to get to orbit, we trained months and months for, and didn't have to use any of that preparation, other than being aware and ready.

There was a moth in there, and it still had its wings crumpled up, and it was just starting to pump its wings up. Life continues in lots of places, and life is a magical thing.

There are some very significant changes in the way the fluids are distributed in our body, the way our heart functions initially, and as well as our bone and muscle.

The Navy's paid for you to go through school, and then they need doctors to go out and take care of people who are in various different parts of the world. I decided to pay back my time first as an undersea medical officer. I was stationed in Scotland.

The microgravity or the very, very low amount of gravity that we have up in space forces some changes in different processes. It forces changes in us as human beings.

Some things are only capable of being done in space.

Examples of that are looking at our Earth from that far away, and understanding the entire processes of storms and weather patterns, and oceans, and coastlines.

Science, for hundreds of years, has spanned the differences between cultures and between countries.

Other than motherhood, the eight years that I spent at the University of Wisconsin, Madison, I have incredibly fond memories of. It's a beautiful place, with four seasons up in Wisconsin. And really wonderful people.

Life science research can be done on multiple platforms.

Since we have a very small number of people flying into space, the more people you have, the better.

It's such a long mission and we get to spend so much time in space.

.. we're doing such exciting research. And I don't want to overemphasize the life science research, but as a physician the life science research that we're doing is extremely exciting.

If you're trying to get someone who's sick with a fever off of a submarine and it's cold and raining outside, the only way in and out of a submarine, generally, is through a fairly narrow hatch.

I've always enjoyed traveling and having experience with different cultures and different people. But it's also a wonderful thing to be able to benefit and enable research, not only in our country but around the world.