No one will burn out doing aerobic running.
It is too much anaerobic running, which the American scholastic athletic system tends to put young athletes through, that burns them out.
The capacity to blunder slightly is the real marvel of DNA.
Without this special attribute, we would still be anaerobic bacteria and there would be no music.
It's a question of spreading the available energy, aerobic and anaerobic, evenly over four minutes. If you run one part too fast, you pay a price. If you run another part more slowly your overall time is slower.