Breakups are a horrible thing for almost everybody I know. For someone who is a love addict, it's debilitating.
— Alanis Morissette

There are so many opportunities in life, that the loss of two or three capabilities is not necessarily debilitating. A handicap can give you the opportunity to focus more on art, writing, or music.
Jim Davis debilitating quote

Indecision is debilitating; it feeds upon itself; it is, one might almost say, habit-forming. Not only that, but it is contagious; it transmits itself to others.
— H. A. Hopf

A population weakened and exhausted by battling against so many obstacles -- whose needs are never satisfied and desires never fulfilled -- is vulnerable to manipulation and regimentation. The struggle for survival is, above all, an exercise that is hugely time-consuming, absorbing and debilitating. If you create these anti-conditions, your rule is guaranteed for a hundred years.
— Ryszard Kapuscinski

I have learned that trying to guess what the boss or the client wants is the most debilitating of all influences in the creation of good advertising.
— Leo Burnett