I hope that some day the practice of producing cowpox in human beings will spread over the world - when that day comes, there will be no more smallpox.

— Edward Jenner

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I shall endeavour still further to prosecute this inquiry, an inquiry I trust not merely speculative, but of sufficient moment to inspire the pleasing hope of its becoming essentially beneficial to mankind.

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While the vaccine discovery was progressive, the joy I felt at the prospect before me of being the instrument destined to take away from the world one of its greatest calamities [smallpox], blended with the fond hope of enjoying independence and domestic peace and happiness, was often so excessive that, in pursuing my favourite subject among the meadows, I have sometimes found myself in a kind of reverie.

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The deviation of man from the state in which he was originally placed by nature seems to have proved to him a prolific source of diseases.

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